bx9 benzoxazinone synthesis 9 []

Thepreparation of different derivatives of can be considered important because they have different kinds ofpharmaceutical, agricultural and industrial applications [1-4]. The synthesisof derivative, 4H-3-benzoxazin-4-one2-(N-), was reported previously by ourteam [5]. In this paper we have used the same method to synthesize 4H-3-benzoxazin-4-one 2-phenyl 5. This synthesis occursin two steps: In the first step, acid 1(4.11g) in 40 ml chloroform was mixed with 4.15 ml anhydrous and 3.48 ml chloride 2 in 10 ml chloroform. In the second step, the resulting 3 (2.41 g) mixed with 100 ml anhydroustoluene, 1.52 ml and 1.84 g chloride 4 is refluxed for one week. Afterpurification, drying with magnesium sulfate, the resulting 5 as a final product is in 30%ether-chloroform solution. Yield 67.8 % (63% overall)

Benzoxazinone Intermediate for the Synthesis of Deferasirox

Boric Acid Catalyzed Synthesis of Benzoxazinone Derivatives

Synthesis and Reactivity of 6 Iodo 4H 3,1 Benzoxazin 4 …

Benzoxazinones and quinazolinones have a wide spectrum of biological activity. In this paper we focused on studying the antimicrobial and anti-inflammatory activities of some newly synthesized benzoxazinone and quinazolinone derivatives. Thus we prepared 2-[α-benzoylaminostyryl]-6,8-dibromo-3,1-benzoxazin-4()-one 2 which underwent a reaction with primary and secondary amines, and hydrazine hydrate to give compounds 3, 4 and 5, respectively. Treatment of 2 with hydroxylamine hydrochloride, formamide and/or NaN3/AcOH afforded compounds 7, 8, 11 and 12, respectively. Also, compound 2 reacted with maleic anhydride, aromatic hydrocarbons and/or active methylene compounds to produce compounds 13, 15ac and 16, respectively. Most of the newly synthesized compounds showed significant antimicrobial and anti-inflammatory activities comparable to ampicillin, mycostatine and indomethacin positive controls.

Synthesis of Benzoxazinone Derivatives: A New Route …

We report the synthesis of sulfuric acid-functionalized silica-coated magnetic nanoparticles (MgFe2O4@SiO2–SO3H) as a catalyst for the microwave-assisted synthesis of pharmacologically active benzoxazinone and benzthioxazinone via multicomponent reactions under solvent-free conditions. The synthesized catalyst was characterized by FT-IR, XRD, SEM, TEM, EDS, TGA and BET analyses which showed that it had spherical shape, uniform morphology and moderate surface area with super-paramagnetic behavior. The catalyst was easily separated by an external magnet and the main accomplishment of the present work is that the catalyst recycled for five cycles while lacking any major loss of its activity.


Synthesis of 4H-3,1-benzoxazin-4-one 2-phenyl Using ..

Molecular design and synthesis of benzoxazinone ..

SYNTHESIS OF A BENZOXAZINONE Last Update: ..