Synthesis of Polymethylmethacrylate spheres covered …

N2 - A photochemical, alternative and eco-compatible approach to perfluoroalkyl derivatives of pyrene ispresented. The perfluoroalkyl chain is regiospecifically introduced at the 1 position of pyrene. Thesynthesized products have been embedded in a polymethylmethacrylate matrix by photocuring at 365nm. Both the photochemical reactions can be considered a “green tool” for the synthetic chemist inorder to obtain materials with prospective optoelectronic applications. The so-obtained composites havebeen the object of a study by UV and fluorescence spectroscopy in order to explore their luminescenceproperties. The small angle X-ray scattering and the transmission electron microscopy techniques wereused to investigate the microstructure. A correlation between the optical and the structural properties isherein presented.

Accelerated synthesis of poly(methyl methacrylate)-b …

01/05/2011 · Microwave initiated synthesis of polymethylmethacrylate grafted ..

The molecular mechanism of ATP synthesis by F1F0 …

N2 - The effects of polymethylmethacrylate (PMMA) exposure upon macrophage viability and function were studied in an attempt to determine what role these cells play in the loosening of cemented arthroplasties. P388D1 murine macrophage cell line was exposed to PMMA and polystyrene particles of similar size and concentration. DNA synthesis following exposure to PMMA or polystyrene was studied by [3H]thymidine incorporation. Macrophage function was studied by analyzing the ability of activated macrophages to kill mast cell targets following particle exposure. Our results demonstrate that exposure of macrophages to PMMA particles in vitro inhibits DNA synthesis and impairs their cytotoxic ability. Histologic examination revealed that macrophages phagocytose both PMMA and sytrene particles, but the former eventually lyse these cells. Our studies suggest that the histologic appearance of macrophages and foreign body giant cells at the bone-cement interface may be secondary to a repetitive cycle of PMMA particle phagocytosis and cell death, similar to that found in a foreign body granulomatous response.

Materials | Free Full-Text | Zinc Oxide—From Synthesis …

AB - The effects of polymethylmethacrylate (PMMA) exposure upon macrophage viability and function were studied in an attempt to determine what role these cells play in the loosening of cemented arthroplasties. P388D1 murine macrophage cell line was exposed to PMMA and polystyrene particles of similar size and concentration. DNA synthesis following exposure to PMMA or polystyrene was studied by [3H]thymidine incorporation. Macrophage function was studied by analyzing the ability of activated macrophages to kill mast cell targets following particle exposure. Our results demonstrate that exposure of macrophages to PMMA particles in vitro inhibits DNA synthesis and impairs their cytotoxic ability. Histologic examination revealed that macrophages phagocytose both PMMA and sytrene particles, but the former eventually lyse these cells. Our studies suggest that the histologic appearance of macrophages and foreign body giant cells at the bone-cement interface may be secondary to a repetitive cycle of PMMA particle phagocytosis and cell death, similar to that found in a foreign body granulomatous response.

Polymerization and Characterization of PMMA. …

The effects of polymethylmethacrylate (PMMA) exposure upon macrophage viability and function were studied in an attempt to determine what role these cells play in the loosening of cemented arthroplasties. P388D1 murine macrophage cell line was exposed to PMMA and polystyrene particles of similar size and concentration. DNA synthesis following exposure to PMMA or polystyrene was studied by [3H]thymidine incorporation. Macrophage function was studied by analyzing the ability of activated macrophages to kill mast cell targets following particle exposure. Our results demonstrate that exposure of macrophages to PMMA particles in vitro inhibits DNA synthesis and impairs their cytotoxic ability. Histologic examination revealed that macrophages phagocytose both PMMA and sytrene particles, but the former eventually lyse these cells. Our studies suggest that the histologic appearance of macrophages and foreign body giant cells at the bone-cement interface may be secondary to a repetitive cycle of PMMA particle phagocytosis and cell death, similar to that found in a foreign body granulomatous response.

Polymethylmethacrylate particles enhance DNA and …

Aseptic loosening of polymethylmethacrylate (PMMA) fixed prosthesis is characterized by formation of a radiolucent fibrous membrane, accumulation of inflammatory cells and osteolysis. Since this membrane is produced by fibroblasts, it is likely that these connective tissue cells play a critical role in the loosening process. Whether fibroblasts form the radiolucent membrane in response to stimulation by PMMA has not yet been established, nor is it known whether fibroblasts play a role in attracting inflammatory cells to the bone-cement interface by secreting chemical mediators. To address this question, we analyzed the in vitro response of normal human fibroblasts to PMMA. Cells were plated with 105/mL Dulbecco minimal essential medium and were incubated 4 h later with PMMA particles, polystyrene (PS) particles, or medium alone. Proliferative capacity monitored by incorporation of 3H-thymidine was significantly increased following a 48 h exposure to PMMA. Protein synthesis determined by incorporation of 14C-leucine and 14C-proline was also increased. In contrast, levels of secreted prostaglandin (PG) E2 assayed immunoenzymatically was not altered by PMMA. Fibroblasts exposed to control PS did not change their proliferative or protein synthetic activity. Fibroblasts internalized PMMA and PS particles without detectable ultrastructural damage. PMMA enhancement of fibroblast proliferative capacity and protein synthetic ability observed in our in vitro assay system suggests similar effects on fibroblasts in vivo.

as cocomponents for the synthesis of denture base materials.

N2 - Aseptic loosening of polymethylmethacrylate (PMMA) fixed prosthesis is characterized by formation of a radiolucent fibrous membrane, accumulation of inflammatory cells and osteolysis. Since this membrane is produced by fibroblasts, it is likely that these connective tissue cells play a critical role in the loosening process. Whether fibroblasts form the radiolucent membrane in response to stimulation by PMMA has not yet been established, nor is it known whether fibroblasts play a role in attracting inflammatory cells to the bone-cement interface by secreting chemical mediators. To address this question, we analyzed the in vitro response of normal human fibroblasts to PMMA. Cells were plated with 105/mL Dulbecco minimal essential medium and were incubated 4 h later with PMMA particles, polystyrene (PS) particles, or medium alone. Proliferative capacity monitored by incorporation of 3H-thymidine was significantly increased following a 48 h exposure to PMMA. Protein synthesis determined by incorporation of 14C-leucine and 14C-proline was also increased. In contrast, levels of secreted prostaglandin (PG) E2 assayed immunoenzymatically was not altered by PMMA. Fibroblasts exposed to control PS did not change their proliferative or protein synthetic activity. Fibroblasts internalized PMMA and PS particles without detectable ultrastructural damage. PMMA enhancement of fibroblast proliferative capacity and protein synthetic ability observed in our in vitro assay system suggests similar effects on fibroblasts in vivo.