GRIGNARD REAGENT & REACTIONS - Adi Chemistry

Preparative Methods: in spite of their commercial availability, solutions of PhMgBr and PhMgCl are frequently prepared from reaction of a phenyl halide and Mg, usually in Et2O or THF.c,e, Preparation of PhMgBr in Et2O is routine, but the formation of PhMgCl from PhCl and magnesium is difficult to initiate and sustain. By contrast, preparation is generally successful in THF. Use of activated Magnesium makes possible otherwise difficult preparations, allows the use of lower temperatures which may minimize undesired reactions with other functional groups in the reagent, and allows the use of Et2O, other less favorable ethers, and hydrocarbons. Stirring Mg under nitrogen is one activation procedure; other effective procedures (chemical treatment of the Mg, preparation of Mg by reduction of salts, use of ethylene bromide as a coreagent during the preparation) can introduce other species.

The chemistry of isatins: a review from 1975 to 1999 - …

Syntheses of triphenylmethanol using the Grignard reagent Phenylmagnesium bromide
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The Chemistry of Isatins: a Review from 1975 to 1999

N2 - The dimer of methyl vinyl ketone, when treated with phenylmagnesium bromide, was converted to the exo and endo isomers of 7-phenyl-5,7-dimethyl-6,8-dioxabicyclo[3.2.1]octane. The x-ray crystallographic examination of the exo isomer provides the first detailed structural data for this interesting bicyclic ketal series. The method of synthesis and the x-ray structural data are provided.

Extraction and Separation of Ephedrine and Pseudoephedrine

The dimer of methyl vinyl ketone, when treated with phenylmagnesium bromide, was converted to the exo and endo isomers of 7-phenyl-5,7-dimethyl-6,8-dioxabicyclo[3.2.1]octane. The x-ray crystallographic examination of the exo isomer provides the first detailed structural data for this interesting bicyclic ketal series. The method of synthesis and the x-ray structural data are provided.

Synthesis of triphenylmethanol from benzophenone and phenylmagnesium bromide.
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Grignard Synthesis of Triphenylmethanol Objective: 1

Grignard Reagent Synthesis Reaction Mechanism - …

Synthesis and applications of 1-iodo-4-MgCl-1,3-dienes …